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Star quarterback aims for division title after historic performance against familiar foe.

After enjoying a well-earned bye week, the Buffalo Bills are set to light up Sunday Night Football tonight at 8:20 PM EST. Awaiting them at home are the San Francisco 49ers, a team currently facing some rough waters.

With a solid 9-2 record, the Bills have more than just a win in sight—they can lock down the AFC East title tonight, thanks to the Miami Dolphins’ Thanksgiving loss to the Green Bay Packers. Securing this would mark their fifth straight division win and keep the chase for the AFC’s No. 1 seed alongside the Kansas City Chiefs very much alive.

Now, don’t let the 49ers’ recent struggles mislead you—they are still a formidable squad. Fred Warner holds court as one of the league’s premier linebackers, and Leonard Floyd, a familiar face to Buffalo fans, makes his return, having played for the Bills last season. However, the injury bug has bitten the 49ers hard, and it’s a question if they can power through on the field.



Commentary for the night’s game comes from a distinguished team on NBC: Mike Tirico on play-by-play, Chris Collinsworth providing color commentary, and Melissa Stark covering the sidelines. For radio listeners, WGR Radio 550 will feature Chris Brown with play-by-play, Eric Wood as the color analyst, and Sal Capaccio reporting from the sidelines. Over on Westwood One Sports, Ryan Radtke and Ross Tucker will handle play-by-play and color analysis, respectively, as per Buffalo Bills PR.

Historically, the Bills versus 49ers clashes have painted an intriguing picture. In 13 encounters, Buffalo holds a narrow series lead at 7-6.

Twice, the Bills have put up over 40 points against the Niners, while San Francisco has hit that mark only once against Buffalo. On home turf, the Bills are 3-2 in five games against the 49ers, with their most recent home loss back in 2008.



Most recently, the Bills have dominated their last two meetings, outscoring San Francisco 79-40. Reflecting on their 2020 battle, Josh Allen was an unstoppable force, completing 80% of his passes for 375 yards and four touchdowns, driving the Bills to a 34-24 victory in San Francisco. With narratives from past and present swirling, tonight’s showdown promises to be a captivating spectacle for all fans watching.